L-Citrulline Malate Side Effects

Citrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. Citrulline is also produced from arginine as a by-product of the reaction catalyzed by NOS family (NOS; EC 1.14.13.39). Citrulline is made from arginine by the enzyme trichohyalin at the inner root sheath and medulla of hair follicles. Arginine is first oxidized into N-hydroxyl-arginine, which is then further oxidized to citrulline concomitant with release of nitric oxide.

General Side Effects

No significant side effects reported.

Suggested Dosage

As L-Citrulline Malate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline Malate for long period.
* ADI: Acceptable Daily Intake
* MTDI: maximum tolerable daily intake
* Data source: JECFA Database of WHO

Special Groups Precaution

Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Citrulline Malate could have any negative effects on these vulnerable groups. It should be safe to use L-Citrulline Malate in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline Malate for long period in food for newborns or pregnant.

GRAS Affirmation: No

Though L-Citrulline Malate is not on FDA’s GRAS exemption list, it’s still widely accepted as safe food additive in many countries including USA with specific limit on dosage.

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