Branched-Chain Amino Acids Side Effects

A branched-chain amino acid (BCAA) is an amino acid having aliphatic side-chains with a branch (a central carbon atom bound to three or more carbon atoms). Among the proteinogenic amino acids, there are three BCAAs: leucine, isoleucine and valine. Non-proteinogenic BCAAs include norvaline and 2-aminoisobutyric acid.

The three proteinogenic BCAAs are among the nine essential amino acids for humans, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals.

General Side Effects

Branched-chain amino acids might affect blood sugar levels which might interfere with blood sugar control during and after surgery. Branched-chain amino acids may cause Branched-chain amino acids in specific groups of individuals.

Suggested Dosage

Ingestion of Branched-Chain Amino Acids in large quantity may hurt our health, please follow the guideline of using Branched-Chain Amino Acids: Estimated average requirement of branched-chain amino acids is 68-144 mg/kg body weight per day for adults
* ADI: Acceptable Daily Intake
* MTDI: maximum tolerable daily intake
* Data source: JECFA Database of WHO

Special Groups Precaution

Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Branched-Chain Amino Acids could have any negative effects on these vulnerable groups. It should be safe to use Branched-Chain Amino Acids in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Branched-Chain Amino Acids for long period in food for newborns or pregnant.

GRAS Affirmation: No

Though Branched-Chain Amino Acids is not on FDA’s GRAS exemption list, it’s still widely accepted as safe food additive in many countries including USA with specific limit on dosage.

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